Interleukin-27: Biological Properties and Clinical Application (SpringerBriefs in Immunology)
Product details
| Management number | 233443775 | Release Date | 2026/06/27 | List Price | US$17.06 | Model Number | 233443775 | ||
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This volume focuses on various aspects of interleukin-27 (IL-27), especially its potential for clinical applications. The authors discuss the downstream signaling from the IL-27 receptor and its molecular targets in immune cells including Th1, Th2, Th17, Treg, Tr1, Tfh, B cells, DCs and macrophages. The inhibition of Th17 cells by IL-27 is vital for the maintenance of the feto-maternal tolerance and the prevention of lupus, multiple sclerosis, autoimmune uveitis, immune thrombocytopenia and atherosclerosis. However, the same inhibitory capabilities compromise the immune response to bacterial pathogens, and IL-27 is a pathogenic factor in sepsis and tuberculosis. Also covered are the conflicting reports on the role of IL-27 in rheumatoid arthritis, the effect of IL-27 on epithelia, which seems to play a role in asthma, psoriasis and inflammatory bowel diseases, and the direct cytotoxic and anti-vascular effects of IL-27, which make it a promising agent for the treatment of cancer. Accordingly, this volume will be of interest to researchers and clinicians alike. Read more
| ISBN10 | 3319396625 |
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| ISBN13 | 978-3319396620 |
| Edition | 1st ed. 2016 |
| Language | English |
| Publisher | Springer |
| Dimensions | 6.1 x 0.22 x 9.25 inches |
| Item Weight | 7.2 ounces |
| Print length | 92 pages |
| Part of series | SpringerBriefs in Immunology |
| Publication date | May 23, 2016 |
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